Microdosing- Panacea or Placebo?

Is it all hype or is there genuine hope for therapeutic application of microdosing?

There’s certainly plenty of ‘conflicting’ information or results available from studies of different methodologies. Here, we begin with an overview of what microdosing is, who does it, and for what purposes. We then review available evidence and summarize benefits and risks of microdosing. Finally, we get more practical and discuss microdosing regimens, measurement of accurate dosing, and ‘set and setting’ consideration to microdosing.

  • from Ben Malcolm, Spirit Pharmacist

Read more

Psilocybin for Alcohol Addiction

New research reveals that the psychedelic compound in magic mushrooms, in combination with talk therapy, could be a promising treatment for people with alcohol addiction.

In a study published Wednesday in JAMA Psychiatry, scientists found that patients taking this drug, called psilocybin, had an 83 percent decline in heavy drinking, while those who took a placebo experienced a 51 percent decline.

Read more

How Psilocybin May Rewire the Brain

“One of the most interesting things we’ve learned about the classic psychedelics is that they have a dramatic effect on the way brain systems synchronize, or move and groove together,” said Matthew Johnson, a professor in psychedelics and consciousness at Johns Hopkins Medicine.

“When someone’s on psilocybin, we see an overall increase in connectivity between areas of the brain that don’t normally communicate well,” Johnson said. “You also see the opposite of that – local networks in the brain that normally interact with each other quite a bit suddenly communicate less.”

Read more

More Psilocybin Research

Studies over the past several years have shown promise in using psilocybin-assisted therapy to treat psychiatric disorders like depression.

A recent follow-up study by Johns Hopkins Medicine researchers found two doses of the hallucinogenic compound coupled with psychotherapy resulted in large decreases in major depressive disorder symptoms for most of the study’s participants.

New research is hinting at how the hallucinogenic compound may facilitate reduced depression symptoms.

Read more