Magic Mushrooms Without the Hallucinations

Scientists are exploring a new way to harness the medical promise of psychedelic compounds without the mind-bending side effects.

Researchers created modified versions of psilocin — the active form of psilocybin from “magic mushrooms” — that still target key serotonin pathways linked to depression and other brain disorders but appear to cause far fewer psychedelic-like effects.

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More on the Therapeutic Potential of Mushrooms

Fred Barrett, a neuroscientist at the Johns Hopkins Center for Psychedelic & Consciousness Research, discusses the revolutionary healing potential of psilocybin, what is not yet known about the compound’s role in treating various psychiatric disorders, the importance of the “therapy” aspect of psychedelic-assisted therapy, and the hurdles that remain to this treatment being accessible to the general public.

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Update on Oregon

In 2020, Oregon was the first state in the U.S. to effectively legalize psilocybin, the hallucinogenic component of magic mushrooms, for therapeutic use.

It has shown to be effective in treating post-traumatic stress disorder, depression and end-of-life anxiety.

Since then, regulations and restrictions for psilocybin treatment have taken shape across the state with many rural counties opting out of providing any psilocybin-related services at all.

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Global Survey 2020 Results: Self-Treatment of LSD and Psilocybin

The Global Drug Survey 2020 is a large online survey on drug use collected between November 2019 and February 2020.

Positive changes were observed across all 17 outcome items, with the strongest benefits on items related to insight and mood. Negative effects were reported by 22.5% of respondents.

High intensity of psychedelic experience, seeking advice before treatment, treating with psilocybin mushrooms and treating post-traumatic stress disorder were associated with higher scores on the self-treatment outcome scale after averaging values across all 17 items.

Younger age, high intensity of experience and treating with LSD were associated with increased number of negative outcomes.

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Psilocybin Mushrooms and Bipolar Disorder

A new study published in the Journal of Psychopharmacology is the first to characterize the psychological impacts of psilocybin among people with bipolar disorder.

The findings indicate that many people with bipolar disorder who consume psilocybin, the primary psychoactive component of psychedelic “magic mushrooms,” believe that the experience is helpful. However, many also report adverse outcomes, such as manic symptoms.

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