Ketamine for Depression

A new brain-imaging study has revealed how ketamine produces its fast antidepressant effects in people with treatment-resistant depression.

Researchers tracked changes in a critical brain receptor that helps neurons communicate and found that ketamine reshapes its activity in specific brain regions tied to mood and reward.

These shifts strongly matched improvements in patients’ symptoms. The findings could help scientists develop better ways to predict who will benefit from ketamine therapy.

Read more

Right Hemisphere and Psychedelics

A new theory suggests that psychedelics promote empathy, insight, and psychological flexibility by making the brain’s right hemisphere temporarily dominant over the left.

Known as HEALS—Hemispheric Annealing and Lateralization Under Psychedelics—this model proposes that psychedelics disrupt the typical hierarchy between hemispheres, releasing the more holistic, emotionally intelligent right side from left-brain control.

Read more