A new brain-imaging study has revealed how ketamine produces its fast antidepressant effects in people with treatment-resistant depression.
Researchers tracked changes in a critical brain receptor that helps neurons communicate and found that ketamine reshapes its activity in specific brain regions tied to mood and reward.
These shifts strongly matched improvements in patients’ symptoms. The findings could help scientists develop better ways to predict who will benefit from ketamine therapy.
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Why do mind-altering drugs make people feel better?
Scientists want to redesign psychedelics so that they don’t induce a trip—but they still improve mental health.
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Keep reading for more info on the plant jurema. In Brazil, a new line of research is using DMT for treatment-resistant depression.
Interestingly, they were extracting it from a plant called jurema-preta (Mimosa tenuiflora), rather than the DMT found in chacruna used in ayahuasca.
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This study sheds light on which post-psychedelic difficulties last longest and what helps people cope.
The findings suggest that while anxiety and panic are among the most disruptive, issues like existential struggle and diminished self-esteem tend to last the longest—often persisting for over a year.
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A new theory suggests that psychedelics promote empathy, insight, and psychological flexibility by making the brain’s right hemisphere temporarily dominant over the left.
Known as HEALS—Hemispheric Annealing and Lateralization Under Psychedelics—this model proposes that psychedelics disrupt the typical hierarchy between hemispheres, releasing the more holistic, emotionally intelligent right side from left-brain control.
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