How Psilocybin May Rewire the Brain

“One of the most interesting things we’ve learned about the classic psychedelics is that they have a dramatic effect on the way brain systems synchronize, or move and groove together,” said Matthew Johnson, a professor in psychedelics and consciousness at Johns Hopkins Medicine.

“When someone’s on psilocybin, we see an overall increase in connectivity between areas of the brain that don’t normally communicate well,” Johnson said. “You also see the opposite of that – local networks in the brain that normally interact with each other quite a bit suddenly communicate less.”

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Podcast on Psychedelics

Podcast on psychedelics: the science, research, and medical implications with Dr. Fred Barrett.

Dr. Frederick Barrett is a cognitive neuroscientist with training in behavioral pharmacology. He has been conducting psychedelic research at Johns Hopkins University since 2013. He has explored the effects of psilocybin on the brain, the effects of LSD on the brain’s response to music, and is currently leading a number of ongoing studies aimed at better understanding the psychological, biological, and neural mechanisms underlying the therapeutic efficacy of psychedelic drugs.

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